„Ein zielgerichtetes Temperaturmanagement bleibt wichtig, aber es besteht jetzt auch die Option,  eine Temperatur von 36°C statt wie bisher 32–34 °C anzustreben. Fieber zu vermeiden bleibt sehr wichtig.“ Zitat aus Leitlinien Kompakt, Reanimation 2015  des German Resuscitation Councils, Seite 26

TTCool ist ein effizientes und geeignetes Werkzeug zur Fiebervermeidung und zur Herstellung der therapeutischen Hypothermie nach Therapiepräferenz des behandelnden Arztes


The Heart.Org – Medscape: Therapeutic Hypothermia

Updated: Apr 30, 2014, Author: Jonathan Adler, MD, MS; Chief Editor: Karlheinz Peter, MD, PhD more




The New England Journal of Medicine:  Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest 

Dec 5 , 2013: Author:  Niklas Nielsen, M.D., Ph.D., Jørn Wetterslev, M.D., Ph.D., Tobias Cronberg, M.D., Ph.D., David Erlinge, M.D., Ph.D., Yvan Gasche, M.D., Christian Hassager, M.D., D.M.Sci., Janneke Horn, M.D., Ph.D., Jan Hovdenes, M.D., Ph.D., Jesper Kjaergaard, M.D., D.M.Sci., Michael Kuiper, M.D., Ph.D., Tommaso Pellis, M.D., Pascal Stammet, M.D., Michael Wanscher, M.D., Ph.D., Matt P. Wise, M.D., D.Phil., Anders Åneman, M.D., Ph.D., Nawaf Al-Subaie, M.D., Søren Boesgaard, M.D., D.M.Sci., John Bro-Jeppesen, M.D., Iole Brunetti, M.D., Jan Frederik Bugge, M.D., Ph.D., Christopher D. Hingston, M.D., Nicole P. Juffermans, M.D., Ph.D., Matty Koopmans, R.N., M.Sc., Lars Køber, M.D., D.M.Sci., Jørund Langørgen, M.D., Gisela Lilja, O.T., Jacob Eifer Møller, M.D., D.M.Sci., Malin Rundgren, M.D., Ph.D., Christian Rylander, M.D., Ph.D., Ondrej Smid, M.D., Christophe Werer, M.D., Per Winkel, M.D., D.M.Sci., and Hans Friberg, M.D., Ph.D., for the TTM Trial Investigators more

N Engl J Med 2013; 369:2197-2206December 5, 2013DOI: 10.1056/NEJMoa1310519

Neurocrit Care. 2014 Oct;21(2):207-10. doi: 10.1007/s12028-014-0001-0.

Risk of thromboembolic events with endovascular cooling catheters in patients with subarachnoid hemorrhage.




Endovascular cooling is currently used for hypothermia treatment and fever reduction therapy. At the same time, little is known about the risks associated to endovascular cooling in patients treated with an endovascular cooling catheter (ECC).


A retrospective chart review of 122 patients with subarachnoid hemorrhage (SAH) treated with an ECC either for therapeutic hypothermia or for fever reduction was performed. ECC-associated thromboembolic events (TEE) such as pulmonary embolism and thrombosis were recorded and compared between patients treated with an ECC and patients treated only with a central venous line (CVL). Additionally, various laboratory parameters were recorded to determine if they might be related to the frequency of TEE’s.


43 Patients were treated with an ECC and 79 with a CVL. Patients in the ECC group suffered more frequently from TEE (37 %) than those with a CVL (5 %). None of the laboratory parameters was associated with an increased TEE risk. The treatment with an ECC alone was a risk factor for a TEE, independent from age as well as from Hunt and Hess grade.


Our data show that the treatment with ECC increases the risk of TEE in SAH patients. Therefore, especially when considered for fever reduction, non-invasive devices for surface cooling should be the first choice.

[PubMed – indexed for MEDLINE]

____________________  Therapeutische Hypothermie – Richtiges Temperaturmanagement bei Patienten nach Herzstillstand 

8. September 2011


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